Center For AIDS Research

October 6 - 13, 2014

The Network News
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October 6 - 13, 2014
Divider Rule Quotes of the Week ...

... It turns out that our bodies ARE a temple. Unfortunately, for most of us it is the Temple of Doom.

-David Vance (when summing up the compelling body of research presented by investigators at CFAR's HIV and Aging conference last week), on the crucial role that regular exercise and weight maintenance turn out to play in healthy aging.

 

... Aging is a furniture problem — our chest drops into our drawers.

-Kevin High (at the same HIV and Aging conference) Divider Rule Kudos ...
 

... to the Emory CFARians who brought home two of the three Top Abstract awards at last week's conference: HIV and Aging: From Mitochondria to the Metropolis. (CFARians from the UAB CFAR snagged the third award)

     Mitochondria

In treating HIV, you can definitely have too much of a good thing. Just ask anyone who has suffered from antiretroviral drug toxicity. Mitochondria -- those helpful, micro-size power plants that make all life possible -- seem to play a key role in promoting drug toxicity. So wouldn't it be wonderful if we could identify potentially helpful drugs that are less likely to cause mitochondrial toxicity before these drugs are advanced to the animal study stage? Check out the Top Abstract that Leda Bassit presented on CFAR HIV Eradication and Reservoirs-supported work that she, Raymond Schinazi, James Kohler, Payel Chatterjee, and collaborators did on:
In Vitro Evaluation of Novel Equilibrative Nucleoside Transporter (ENT) Inhibitors that Reduce Mitochondrial Toxicity of Nucleoside Analog Antiretroviral Drugs


Implementation Cascade for the Continuum of Care     
Illustration from Medscape article "Prevention of HIV
Acquisition: Behavioral, Biomedical, and Other Interventions"
     

We've all seen the depressing down slope in HIV Care Continuum models. But what happens if you stratify the benchmarks by age? Are double nickel Americans (age 55+) MORE or LESS likely to be virally suppressed than individuals who are less birthday-endowed (13-54)? Check out the Top Abstract that Jane Kelly presented on work that she, David Maggio, Ken Lazarus, and Joana Yu did on:
The HIV Care Continuum for People Living with HIV (PLWH) Aged 55 Years and Older in Georgia, 2012. Spoiler alert: Age Rocks!

. Divider Rule In other news...

Happy Birthday

... to John Altman (October 6); Eugene Huang (October 10); and Kirk Elifson (October 12).

Birthdays are good for your health ... research shows that people who have the most birthdays live the longest. Enjoy yours!

     CHRIS logo

Carlos del Rio gave the Keynote Lecture ("The past, present and future of global health engagement by academic institutions") at the 2014 Inter-CFAR HIV Research in International Settings (CHRIS) meeting on October 1 in San Diego.

Guido Silvestri     


 
The Emerald City in HIV research these days is a reliable method for obliterating latently infected cells that hang around in hiding even when a person's viral load is (apparently) nonexistant because of HAART. Guido Silvestri has just gotten new R21 funding to investigate, in an SIV-infected rhesus macaque model, the potential of type 1 interferon as a novel intervention for targeting those pesky, persistent reservoirs. (1R21AI116200-01).
For more about the monkey business Guido and his colleagues are engaged in, see this week's "Focus On" section.

Divider Rule Bulletin Board...

bulletin board

Your Opinion Sought: Compensating Inmates for Research
Investigators at UNC are seeking to survey researchers on their attitudes, beliefs, and practices regarding providing financial incentives for incarcerated research participants. The results of this survey will help inform ethical correctional research practices. The survey is available until 10/17/2014 by
clicking this link.

INFORMED CONSENT: The survey will take you approximately 5 minutes to complete. You will not receive any financial incentives for completing this survey. By beginning this survey, you are acknowledging that you have read the above information and that you agree to participate in this research. Your participation is strictly voluntary and your responses will be anonymous. If you have any questions or difficulties, please contact Becky L. White at bls@med.unc.edu, 919-843-8602.

Divider Rule Government News...

Government News

     CDC

No CDC news this week.


     Georgia


No State news this week.


 

NIH     

The new NIH fiscal year starts today and we are now officially operating under a Continuing Resolution, at least through December 11. According to NOT-OD-15-001, the resolution calls for NIH funding at 99.9 percent of the FY 2014 enacted level.

WHAT THIS MEANS FOR YOU: Non-competing research awards will be funded at a level below what it says on your most recent NOA (generally up to 90% of the previously committed level). Upward adjustments to awarded levels will be considered after FY 2015 appropriations are enacted.

Divider Rule Focus On...
Better Living Through Radiation

Focus On...    
     Maud Mavigner     Ben Watkins
 Maud Mavigner Ben Watkins

 

 

 

In a first of its kind, proof-of-concept study facilitated by the CFAR Immunology Core and the Pre-Clinical lab of the CFAR Virology and Molecular Biomarkers Core, CFARians are working to determine if ART and whole body radiation plus a stem cell transplant can return life-before-SHIV to infected Rhesus Macaques.

Specifically, whether a non-human primate model can successfully be used to replicate the HIV eradication strategy used on the Berlin patient.

As PLOS Pathogen publication Co-first authors Maud Mavigner and Ben Watkins describe in Persistence of Virus Reservoirs in ART-Treated SHIV-Infected Rhesus Macaques after Autologous Hematopoietic Stem Cell Transplant, it MAY be successful. Maybe.

WHAT THEY DID: Guido Silvestri, Maud Mavigner, Ben Watkins, Benton Lawson, Thera Lee, Ann Chahroudi, and Leslie Kean: a) harvested stem cells from 3 healthy rhesus macaques (RM), b) infected the RM with SHIV, c) treated the infection with ART to reduce viral load, d) thoroughly nuked the RM to eliminate almost all (94-99%) of the virus' fave rave cellular targets (i.e. circulating CD4+ T-cells), and then e) transplanted the RM with their own pre-SHIV-infection stem cells.

RESULT: While two of the three study subjects exhibited depressingly vigorous viral rebound after interruption of ART, aprés-nuking and stem cell transplant, one of them didn't.

Read Polar Opposite headlines interpreting the outcome:
In EurekAlert
In the Emory News

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Research

Request for Information

December 1 (deadline)
Sponsor: NIH/NIMHD
NOT-MD-14-010
Behavioral Interventions to Prevent HIV Infection among Diverse Young Men Who Have Sex with Men (MSM)


Funding Opps

NEW LISTINGS:
STANDARD AIDS DATES

Sponsor: NIH/NIDA
R21
R03
R01
Epidemiology of Drug Abuse

 

NEW LISTINGS:
OTHER

March 9 (LOI)
Sponsor: NIH/NIDDK
R01
Innovative Research in HIV in Kidney, Urology and Hematology


PREVIOUS LISTINGS:
ALL

See previously advertised Funding Opportunities in Network News archived issues.

top Divider Rule pubs

Recent Pubs
that link to the CFAR grant
(P30 AI050409)

25246494
Mylvaganam, Geetha H; Velu, Vijayakumar; Hong, Jung-Joo; Sadagopal, Shanmugalakshmi; Kwa, Suefen; Basu, Rahul; Lawson, Benton; Villinger, Francois; Amara, Rama Rao. Diminished Viral Control during Simian Immunodeficiency Virus Infection Is Associated with Aberrant PD-1hi CD4 T Cell Enrichment in the Lymphoid Follicles of the Rectal Mucosa.
Journal of immunology (Baltimore, Md. : 1950). 2014 Sep 22;

25170175
Huang, Yijian. Bootstrap for the case-cohort design.
Biometrika. 2014 Jun; 101 (2) 465-476.

25069147
Finneran, Catherine; Stephenson, Rob. Antecedents of intimate partner violence among gay and bisexual men.
Violence and victims. 2014; 29 (3) 422-35

24778120
Remick, Joshua; Georgiopoulou, Vasiliki; Marti, Catherine; Ofotokun, Igho; Kalogeropoulos, Andreas; Lewis, William; Butler, Javed. Heart failure in patients with human immunodeficiency virus infection: epidemiology, pathophysiology, treatment, and future research.
Circulation. 2014 Apr 29; 129 (17) 1781-9

25160901
Jennings, Larissa; Rompalo, Anne M; Wang, Jing; Hughes, James; Adimora, Adaora A; Hodder, Sally; Soto-Torres, Lydia E; Frew, Paula M; Haley, Danielle F; HIV Prevention Trials Network (HPTN 064) Women's HIV SeroIncidence Study (ISIS). Prevalence and Correlates of Knowledge of Male Partner HIV Testing and Serostatus Among African-American Women Living in High Poverty, High HIV Prevalence Communities (HPTN 064).
AIDS and behavior. 2014 Aug 27.

24953143
Ziegler, Thomas R; McComsey, Grace A; Frediani, Jennifer K; Millson, Erin C; Tangpricha, Vin; Eckard, Allison Ross. Habitual Nutrient Intake in HIV-Infected Youth and Associations with HIV-Related Factors.
AIDS research and human retroviruses. 2014 Sep; 30 (9) 888-95;

24643223
Sheth, Anandi N; Evans-Strickfaden, Tammy; Haaland, Richard; Martin, Amy; Gatcliffe, Chelsea; Adesoye, Adebola; Omondi, Michael W; Lupo, L Davis; Danavall, Damien; Easley, Kirk; Chen, Cheng-Yen; Pau, Chou-Pong; Hart, Clyde; Ofotokun, Igho. HIV-1 genital shedding is suppressed in the setting of high genital antiretroviral drug concentrations throughout the menstrual cycle.
The Journal of infectious diseases. 2014 Sep 1; 210 (5) 736-44

24659628
Hu, Zhaoyong; Klein, Janet D; Mitch, William E; Zhang, Liping; Martinez, Ivan; Wang, Xiaonan H. MicroRNA-29 induces cellular senescence in aging muscle through multiple signaling pathways.
Aging. 2014 Mar; 6 (3) 160-75

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Calendar Upcoming Events
October 8
10:00am
Onsite Testing Opportunity
Rapid HIV Testing
Location: Coca Cola Commons (lower level of the DUC)

October 9
No ID Seminar this Week

October 10 - Abstract deadline (prizes! money!)
October 23-24 - Meeting New Listing
Symposium
Scientific Research and Academic Development
Host: Winship Cancer Institute
Location: Auditorium, Health Sciences Research Bldg
Cost: Free!
Information and Registration

October 13 (Extended abstract deadline)
December 9-12 (Meeting)
Conference
HIV DART 2014
Location: Ritz-Carlton, Key Biscayne (New Location*)
*Cabo San Lucas took a direct hit from Hurricane Odile
Website


Calendar Farther Down the Road
October 15-17
Conference
Strategies for an HIV Cure
Host: NIH/NIAID
Location: Bethesda, MD
Flyer

October 16 New Listing
12:00 - 1:00
Raymond Schinazi Distinguished Lectureship
Viruses and microRNAs
Speaker: Bryan Cullen, PhD (Duke)
Location: Auditorium, Health Sciences Research Building

October 16 New Listing
2:00 - 3:00
Webinar
Improving Health & Quality of Life of Individuals with Multiple Chronic Conditions
Toll Free Number: 800-857-0455;
Participant passcode: 8423024
Web Access: Click this Link

October 16
CFAR Network Pizza Party
Fitness Program
See details in Spotlight below

October 20 (Abstract deadline)
December 8-9 (Meeting)
Symposium
2014 Inter-CFAR Collaboration on HIV Research in Women
Location: New York
Website

October 21
12:00 - 12:50
HIV-related GFE Reports
Contraceptive Needs of Female Sex Workers in
   Higali, Rwanda

   (Courtney Boudreau / GLEPI)
Evaluation of Acceptability of the E-Fingerprinting
   Biometric System Among Female Sex Workers
   and Single, Pregnant Women in Lusaka, Zambia

   (Enoch Chen / GLEPI)
Location: RSPH/CNR/Rm 1000

October 21
12:00 - 12:50
HIV-related GFE Reports
Assessment of Integration of HIV Prevention
   Strategies & Family Planning Services in Kigali,
   Rwanda

   (Emily Kehoe / GH)
Location: RSPH/CNR/Rm 1000

October 23-24
8th Annual SBSRN National Meeting
Disparities in Research, Clinical Treatment, Prevention and Policies: A Call to Action
Host: UCLA CFAR
Location: Los Angeles
Information and Registration

October 27
12:00 - 12:50
HIV-related GFE Reports
Perceptions of HIV risk factors & Prevention
   Among Single, Sexually Active Women

   (Sara Robbins / GH)
Evaluation & Implementation of Follow‐up
   Sampling for Couples' Voluntary HIV Counselling
   & Testing

   (Matthew Pham / EPI)
Location: RSPH/CNR/Rm 1000

October 28
12:00 - 12:50
HIV-related GFE Reports
Roll Out of Trial to Assess Effectiveness of
   Concordant Negative Couples' Intervention
   on HIV Prevention

   (Sarah Gojer / BSHE)
Increasing Usage of Long Acting Reversible
   Contraceptives in Zambia

   (Vanetta Thomas / BSHE)
Assessing Individual and Environmental Factors
   that Contribute to Condom Use Among Female
   Sex Workers in Lusaka and Ndola, Zambia

   (Sunni Wenson / BSHE)
Location: RSPH/CNR/Rm 1000

October 30 (Early reg deadline)
December 9 (Abstract deadline)
January 26-27 (Meeting)
Conference
Innovation in HIV and Viral Hepatitis
Location: Milan, Italy
Website

October 31 (Abstract deadline)
April 13-14 (Meeting)
Conference
Georgia Public Health Association
Website

November 11
12:00 - 12:50
HIV-related GFE Report
Maternal Perceptions of Sexual Norms and
   Expectations in Soweto, Johannesburg, South Africa

   (Katharine Chiseri / BSHE)
Location: RSPH/CNR/Rm 1000

November 11-14 (Meeting)
Symposium
32nd Annual Symposium on Nonhuman Primate Models for AIDS
Host: Oregon National Primate Research Center
Location: Portland, OR
Website

November 17 (Class #1)
November 24 (Class #2)
Tutorial
NIH-K Grant Writing
Read More About It

November 25
12:00 - 12:50
HIV-related GFE Report
Understand Personal Decision‐Making on
   Female Condom Use in Cape Town, South Africa

   (Julia Martin / GH)
Location: RSPH/CNR/Rm 1000


December 2 (Late Breaker opens)
January 8 (Late Breaker deadline)
February 23-26 (Meeting)
Conference
CROI 2015
Location: Seattle
Website

December 3-4 (Meeting)
Symposium
Exploring Realistic Expectations: The Implications of TasP, PrEP and PEP
Target Audience: Medical and Allied Health Professionals
Host: Empowerment Resource Center
Location: Loudermilk Center, Atlanta
Flyer
Registration

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Spotlight

Spotlight! | 10/16/14 CFAR Network Pizza Party

     Pizza Party logo


Meeting Host:
CFAR Immunology Core

Count Me In!
Click Here to Register

starring

Mario Roederer           Under Construction:
The Genetic Architecture of the Human Immune System ... Building Mechanistic Bridges to Autoimmunity and Disease Pathogenesis

Mario Roederer, PhD
Chief, ImmunoTechnology Section
Vaccine Research Center, NIH/NIAID


Chinglai Yang           Getting in Shape:
Induction of Broadly HIV Neutralizing Antibodies Against Conserved Epitopes in the MPER of HIV Env

Chinglai Yang, PhD
Assistant Professor (Micro/Bio)
Emory School of Medicine


Sudhir Kasturi           Endurance Challenge:
Programming Durable Humoral Immunity in HIV Vaccines

Sudhir Kasturi, PhD
Assistant Research Professor (EVC)
Yerkes National Primate Research Center


Location: RSPH/CNR, Room 1000

Agenda:
5:30 — Pizza and Posters:

6:00 — Sound of ringing triangle causes members to channel their inner sheepdog and help herd other members and their guests to room 1000

8:00 — Adjourn for more networking and a dissection of the evening's trio of talks

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CFAR logo

The Network News is a periodic email, detailing HIV/AIDS related events, funding opportunities, and achievements of CFAR members. If you have items that you wish to have included, please send them to us at cfar@emory.edu by Friday of each week. Please put "The Network News" in the subject line.

The Network News is distributed to CFAR members by email every Monday. Except when it isn't.

Editor, Kimberley Sessions Hagen, EdD

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Emory University Center for AIDS Research Emory University Center for AIDS Research