Center For AIDS Research

November 3-10, 2014

The Network News
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November 3-10, 2014
Divider Rule Observation of the Week ...
  
Reality Check
Fear	  9: Hospitalizations from Ebola to date (US)
1: Deaths from Ebola to date (US)
> 200,000: Hospitalizations from Influenza, annually (US)
109: Child deaths from Influenza (US)
2013-2014 flu season (US)

Set a Good "Reality Check" Example for the Public: Get Your Flu Shot

Divider Rule Kudos ...

... to two CFARians who are going to have order bigger business cards:

     Wendy Armstrong

Wendy Armstrong, Medical Director of the Ponce Center and Site Director (Ponce) for the CFAR Clinial Research Core, has been named vice chair of education and integration in the Dept of Medicine (SOM) where she will integrate research and care into departmental educational efforts.

Ted Johnson     


Ted Johnson, Division Director of Geriatric Medicine and Gerontology (SOM) and charter member of CFAR's HIV and Aging IRG, has been tapped to be physician director of Emory Medicine Primary Care and Population Health AND chair of the Department of Family and Preventive Medicine (SOM).



     Rafi Ahmed

... AND to a CFARian who has recently been Institute-alized.

CFARian Rafi Ahmed (along with SOM Dean Chris Larsen) has recently been named to the prestigious Institute of Medicine. Rafi's work on memory T cell differentiation and anti-viral T and B cell immunity is supported by the CFAR Immunology Core.
CFARians make up 36% of Emory's IOM cohort. Hail Fellows well met!

Divider Rule In other news...

Happy Birthday

... to Galina Terbova (November 3), Mary Galinsky (November 5), and Tianwei Yu (November 6).

Get ready, get set, GO! (You have 584 million miles to go around the sun before your next birthday; better get started)


     Mirko Paiardini    Mike Lederman

Q: What do multiple sclerosis and HIV have in common?
A: Hopefully, FTY720. Mirko Paiardini and Mike Lederman (Case Western Reserve CFAR) are dual PIs on new R21 funding for Targeting Cytolytic Cells to Lymphoid Sites of HIV Persistance (1R21AI116171-01). Their project intends to re-purpose FTY720, a molecule that is already FDA-approved for use in multiple sclerosis to, hopefully, initiate a process that will allow assassin (good guy) cells to recognize and destroy HIV expressing (bad guy) cells that are hiding out in the lymphoid tissues of SIV-infected macaques.
Future Alert: the fact that FTY720 is already FDA approved could hasten translation into humans.

 

    

Speaking of Mirko ... the latest CFAR-attributed paper coming from his group is featured on the home page of PLOS Pathogens. Congratulations to co-first authors Luca Micci, Xavier Alvarez, and Robin Iriele (and a host of other CFARians). See full citation in the publication section.

 

     Truvada

Remember how happy everyone felt when the iPrEx trial showed that HIV negative MSM on a daily diet of Truvada® reduced their risk for infection by 42%? Well, wouldn't it be great if a man who either couldn't afford or remember to take a pill every single day could at least come close to matching the benefit simply by taking the drug at the time he had sex? Well, guess what ... reality seems to be even BETTER than that. Following early closure of Britan's PROUD study, the Canadian (Montreal) and French sites of the IPERGAY study have announced that they are stopping the trial of "on demand" Truvada® early because the reduction in the risk of HIV infection in the experimental arm of the study was so significant that it wouldn't be ethical to continue providing any participants with placebo; in fact early analysis indicates a risk reduction "much higher than the one observed in the iPrEx trial!" Zowie! How often does it work out that the better option might be the cheaper and easier one?
Read More About It

Divider Rule Bulletin Board...

bulletin board

Faculty Applicants Sought: RSPH/BSHE
The Department of Behavioral Science and Health Education (RSPH) is seeking applicants for 2-3 for tenured or tenure track faculty appointments at the academic rank of Assistant, Associate, or Full Professor. Priority will be given to applicants with conceptual and methodological expertise including: multi-level modeling, macro-social determinants of health, intervention development, dissemination and implementation, bio-psychosocial influences, ubiquitous technologies, life course development, social network methods, and health disparities.
Read the Recruitment Ad

Care Package Items Sought: Overseas Troops
In honor of Veteran's Day, there is a care package drive being held at Goizueta Business School Commons to support the troops overseas. A list of items provided by a veteran who has been there include: "Individual packets of crystal light or anything they can mix with water (you have to drink tons of water and it gets old); Individual packets of mustard, relish, hot sauce and ketchup (put them in a zip lock bag in case it explodes it won’t ruin everything else); Deodorant; Toothpaste; Soap; Playing cards; Beef jerky; Nuts of any kind; Tuna fish snack packs; Other snack stuff that won’t go bad and will travel well (don’t send anything that will melt or explode); Sore throat lozenges (medical ran out while I was in Afghanistan – the air is really dusty and dry); Pringles; Q-tips (used not just for ears but also for cleaning weapons, comm gear, etc.)."
Additional ideas

Divider Rule Government News...

Government News

     CDC

No CDC news this week


     Georgia

No State news this week


NIH     

No NIH news this week

Divider Rule Focus On...
The CFAR Psychiatric Disorders Co-Morbid with HIV IRG

Focus On...    
     Gretchen Neigh

Director: Gretchen Neigh

Why is there such a high prevalence of psychiatric disorders in people with HIV? No one knows for sure but it is frequently attributed to exposure to high levels of chronic stress due to stigma, poor social support, socioeconomic status, and early life abuse, trauma, and/or violence.

Sounds right but the newly formed Psychiatric Disorders Co-Morbid with HIV Interdisciplinary Research Group wants to take a closer look under the hood.

To do this, they are bringing together experts in the study of HIV (YOU PERHAPS?) and experts in the study of the neurobiology of chronic stress and psychiatric disease with a goal of creating a forum in which to design transformative research that will ultimately identify points of intervention to improve both physical and mental health in individuals living with HIV.

How cool is that?

Although still an infant in CFAR-years, the group has already initiated three activities aimed at bringing more research attention to this critical issue:

First, there will be a symposium on the neurobiological mechanisms of psychiatric disorders co-morbid with HIV at the 2015 Society for NeuroImmune Pharmacology Meeting in Miami next April. This session will be headed by IRG chair Gretchen Neigh, who, along with fellow IRG member Jennifer Felger, will give presentations.

Second, the IRG is looking to develop an R01 application to assess the interactions between trauma and HIV in the context of PTSD pathfophysiology. This project is a collaboration with the Grady Trauma Project.

Third, a special issue of Neurobiology of Disease is being commissioned entitled “Neurobiological Mechanisms of HIV-associated Neuropsychiatric and Neurocognitive Disorders.” If you have suggestions of individuals to invite to contribute to this special issue, please email gmccand@emory.edu.

Want to join the IRG? Email Gretchen Neigh

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Research

Request for Information

December 1 (deadline)
Sponsor: NIH/NIMHD
NOT-MD-14-010
Behavioral Interventions to Prevent HIV Infection among Diverse Young Men Who Have Sex with Men (MSM)


Funding Opps

NEW LISTINGS:
STANDARD AIDS DATES


NONE


MEDICAL STUDENTS:
January 13 (App)
Sponsor: Doris Duke
1 year award
International Clinical Research Fellowship

JUNIOR FACULTY:
December 12 (App)
Sponsor: Gilead
2-year awards
Gilead Sciences Research Scholars Program in HIV

OTHER:
January 5 (Concept)
Sponsor: UAB CFAR & Pepper Centers
Pilot Awards
HIV/Aging Pilot Program

March 9 (LOI)
Sponsor: NIH/NIDDK
R01
Elucidating HIV and HIV-treatment Associated Metabolic/Endocrine Dysfunction


PREVIOUS LISTINGS:
ALL

See previously advertised Funding Opportunities in Network News archived issues.

top Divider Rule pubs

Recent Pubs
that link to the CFAR grant
(P30 AI050409)

25356757
Micci L, Alvarez X, Iriele RI, Ortiz AM, Ryan ES, McGary CS, Deleage C, McAtee BB, He T, Apetrei C, Easley K, Pahwa S, Collman RG, Derdeyn CA, Davenport MP, Estes JD, Silvestri G, Lackner AA, Paiardini M. CD4 Depletion in SIV-Infected Macaques Results in Macrophage and Microglia Infection with Rapid Turnover of Infected Cells.
PLoS Pathog. 2014 Oct 30;10(10):e1004467.

25348797
Grey JA, Rothenberg R, Sullivan PS, Rosenberg ES. Racial Differences in the Accuracy of Perceived Partner HIV Status among Men Who Have Sex with Men (MSM) in Atlanta, Georgia.
J Int Assoc Provid AIDS Care. 2014 Oct 27. pii: 2325957414555226. [Epub ahead of print].

25246494
Mylvaganam, GH; Velu, V; Hong, J-J; Sadagopal, S; Kwa, S; Basu, R; Lawson, B; Villinger, F; Amara, RR. Diminished Viral Control during Simian Immunodeficiency Virus Infection Is Associated with Aberrant PD-1hi CD4 T Cell Enrichment in the Lymphoid Follicles of the Rectal Mucosa.
Journal of immunology (Baltimore, Md. : 1950). 2014 Nov 1; 193 (9) 4527-36

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Calendar Upcoming Events
November 3 (Abstract Deadline)
February 21-22 (Meeting)
CROI Satellite Event
XXIV International HIV Drug Resistance Workshop
Location: Seattle
Website

November 3
12:00 (lunch at 11:45)
Seminar
Early Antiretroviral Therapy Limits Viral Reservoir in SIV-infected Macaques
Starring: Afam Okoye, PhD (VGTI, Oregon)
    Candidate: NHP Cure Program
Host: Division of Microbiology & Immunology
Location: Yerkes/Bourne Seminar Room

November 3
4:30 - 6:00pm
Faculty Salon
An Exchange of Ideas and Good Conversation, Enhanced with Refreshments and Collegiatily
Location: Center for Ethics Common Room
Invitation (No RSVP needed)
Host: Claire Sterk

November 6
8:00am
ID Seminar
Maternal Immunization
Starring: Saad Omer
Location: RSPH / GCR / Rita Anne Rollins Room

Calendar Farther Down the Road
November 11
10:45am
Honoring Our Veterans
Veterans Salute the Flag with a Special Word from Campus Leadership and Alumni
Location: Flagpole at the Quad

November 11-14
Symposium
32nd Annual Symposium on Nonhuman Primate Models for AIDS
Host: Oregon National Primate Research Center
Location: Portland, OR
Website

November 13 New Listing
12:00
Webinar
Overview of the Informed Consent Process
Host: Emory IRB
Link (click at time of webinar)

November 17 (Class #1)
November 24 (Class #2)
Tutorial
NIH-K Grant Writing
Read More About It

November 19
7:00pm
Discussion
Blueprint Dialogue
   Conversation between activist Black gay and bisexual
   men of different generations to share stories,
   experiences, and lessons learned

Location: Phillip Rush Center
   1530 DeKalb Ave NE, Atlanta

November 20
CFAR Network Pizza Party
HIV & Women
See details in Spotlight below

December 2 (Late Breaker opens)
January 8 (Late Breaker deadline)
February 23-26 (Meeting)
Conference
CROI 2015
Location: Seattle
Website

December 3 New Listing
6:00pm
VDC Meeting
Nietzsche, Goldilocks and the Quest for an AIDS Vaccine: Lessons Learned from Live Attenuated SIV
Starring: R. Paul Johnson, MD
    Director, Yerkes National Primate Research Center
Advance registration required

December 3-4 (Meeting)
Symposium
Exploring Realistic Expectations: The Implications of TasP, PrEP and PEP
Target Audience: Medical and Allied Health Professionals
Host: Empowerment Resource Center
Location: Loudermilk Center, Atlanta
Flyer
Registration

December 8-9 (Meeting)
Symposium
2014 Inter-CFAR Collaboration on HIV Research in Women
Location: New York
Website

December 10
7:00pm
Film Series Screening
No Regret
   Features prominent Black gay men telling their stories
   about being HIV positive

Location: Phillip Rush Center Annex
   1530 DeKalb Ave NE, Atlanta

December 9-12
Conference
HIV DART 2014
Location: Ritz-Carlton, Key Biscayne
Website

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Spotlight Spotlight

Spotlight! | CFAR Network Pizza Party - Thursday, November 20

     Pizza Party logo

Meeting Host:
CFAR HIV & Women Scientific Working Group /
Women's Interagency Health Study

Count Me In!
Click Here to Register

starring

Claire Pomeroy           An Epidemic Without Headlines:
Confronting the Crisis of HIV/AIDS in Women

Claire Pomeroy, MD, MBA
President
Albert and Mary Lasker Foundation


Anandi Sheth           Side Effects - Part I:
Can PrEP Drugs Modulate Genital Tract HIV Immunity?

Anandi Sheth, MD
Assistant Professor (Infectious Disease)
Emory School of Medicine


Kate Michel           Side Effects - Part II:
Can Hormonal Contraceptives Modulate the Anti-HIV Response of the Mucosal Immune System

Kate Michel, PhD
MPH Candidate (Global Epidemiology)
Rollins School of Public Health


Location: RSPH/CNR, Room 1000

Agenda:
5:30 — Pizza and Posters:

6:00 — Sound of ringing triangle causes members to channel their inner sheepdog and help herd other members and their guests to room 1000

8:00 — Adjourn for more networking and a dissection of the evening's trio of talks

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CFAR logo

The Network News is a periodic email, detailing HIV/AIDS related events, funding opportunities, and achievements of CFAR members. If you have items that you wish to have included, please send them to us at cfar@emory.edu by Friday of each week. Please put "The Network News" in the subject line.

The Network News is distributed to CFAR members by email every Monday. Except when it isn't.

Editor, Kimberley Sessions Hagen, EdD

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Emory University Center for AIDS Research Emory University Center for AIDS Research