Center For AIDS Research

May 20, 2020

The Network News
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Please remember to cite the CFAR. Citing the CFAR grant number (AI050409) on all publications and presentations that benefited from any level of Emory CFAR consultation, services, materials, mentorship, or funding is crucial in ensuring our continued support from NIH.

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May 20, 2020
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"It's not an AIDS vaccine

but it may be the closest thing to one so far"

- Jon Cohen (Science Magazine)


"HPTN 083 is a

practice changing, transformative study"

- Carlos del Rio (HPTN 083 Ponce Center Site Director)



BREAKING NEWS...

Given Every Two Months, Injectable PrEP Drug Cabotegravir Appears More Effective Than Daily Oral PrEP (Healio)

"Long-Acting Injectable Cabotegravir Is Highly Effective for the Prevention of HIV Infection in Cisgender Men and Transgender Women Who Have Sex With Men.
Independent Data and Safety Monitoring Board Recommends Unblinding Study Participants.
" (HPTN Press Release)

                 HPTN 083 logo     
                           


Kudos to Colleen Kelley (Hope Clinic), Carlos del Rio (Ponce Clinic), and Eileen Dunne (Silom Community Clinic, Bangkok Thailand), on the parts they played in HPTN 083, a pivotal study that is shaping up to be a HUGE step forward in efficacious options for PrEP use.


                                  
     Colleen Kelley      Carlos del Rio      Eileen Dunne     
     Colleen Kelley      Carlos del Rio      Eileen Dunne     
                                  

Cabotegravir is a long-acting (2 months) injectable PrEP drug that the HPTN was studying in 4,570 cisgender men and transgender women who have sex with men in Argentina, Brazil, Peru, Thailand, the U.S., Vietnam, and South Africa.

"Was" studying because last Thursday the HPTN 083 DSMB met, looked at data showing that, of the 50 total new HIV infections that had occured to date in the >4,500 study subjects, only 12 of them had occured in people on Cabotegravir, promptly concluded that the study had met its objectives, and recommended the study be stopped immediately and participants unblinded.

The Emory-CDC HIV Clinical Trials Unit enrolled ~7% of the study participants through three of our clinical research sites: 86 at the Hope Clinic (Colleen Kelley, Investigator of Record [IOR]), 35 at the Ponce Center (Carlos del Rio, IOR), and 203 at the Silom Community Clinic in Bangkok, Thailand (Eileen Dunne, IOR).

We can see the ads now ...
Make mine a CAB!
Cabotegravir, the PrEP Cabernet
.

     Cabernet     

Read More About It:
HPTN 083
ViiV Press Release
HPTN Press Release
Jon Cohen article
Carlos del Rio article

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HPTN 083 Questions ...
              
              
     Melanie Thompson     
     Melanie Thompson     
              


Re: HPTN 083, Melanie Thompson, Principal investigator for the AIDS Research Consortium of Atlanta, is pleased about the announcement, but she also points out that "assuming the data survive scrutiny, implementation issues must be rapidly addressed," and asks some very provocative questions.

Here's a teaser...

• How will PrEP users and clinicians know who is likely to benefit from cabotegravir PrEP?

• Adherence will still be an issue, just not daily. What is a safe window for missed Cabotegravir injections?

• How much will Cabotegravir cost and who pays?

Will it work in cisgender women?


Read More About It:
Melanie Thompson's "Perspective" piece in Healio

 
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Front & Center ... Nadine Rouphael

              
     Nadine Rouphael     
     Nadine Rouphael     
              

School of Medicine Associate Professor (Infectious Disease) Nadine Rouphael, is:

Interim Director of the Emory Hope Clinic

MPI of Emory's NIH/NIAID-funded Vaccine and Treatment Evaluation Unit (UM1AI148576),

Director of Emory's Human Immunology Project Consortium (HIPC) Clinical Core,

Associate Director of Emory's Vaccinology T32 Training Program, and

MPI of Emory's NIAID-funded StARR Program.


 

Nadine's research focuses on antimicrobial resistance in hospital settings, translational research on innate immunity, immune aging, and correlates of protection against encapsulated bacteria.

 
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From the Twittersphere...
              
    Logo     
              
              
    CNN     
              

              
    Older Americans Month

Speaking of Aging with HIV ... CFAR Anna Rubtsova has a CFAR Developmental Core award to research From Surviving to Thriving (FROST): Correlates of Successful Aging among Older Women Living with HIV.
Read More About It

    
 
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Mentoring Moment... Center for Faculty Development and Excellence

     Mentoring Moment...    
         

              
    Overwhelmed     
              

Writing and Scholarly Productivity During the Pandemic

In this 30 minute webinar, CFDE's Allison Adams presents a framework designed help you decide what is possible for your scholarly productivity, given the new and unprecedented levels of distraction and anxiety that may interfere.

Then Allison discusses ways of, at minimum, staying connected to your writing work so that you don't completely lose momentum, and at best, re-establishing your practice and habits in this extraordinary time.

View the Recording

 
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Community Corner... Georgia CTSA & Inter-CFAR Collaborative

Community Corner       
             

Community Engaged Research

Jumpstarting Success
In 2019, the U.S. Department of Health and Human Services (HHS), through CDC, awarded $16.5 million to state and local health departments to build the foundation for Ending the HIV Epidemic (EHE) and set the United States on a path for progress.

One of the sites is DeKalb County, GA.

Check out what our EHE money has been used for so far

 
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In Case You Missed It...
     ICYMI    
     Faith Over Fear     
    

Watch the Webinar (1:01:49).

 
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Research

Funding Opps

NIH FUNDING:
Standard AIDS Deadlines

Sponsor: Multiple
Clinical Trials: Not Allowed
FOA: PA-20-149
HIV Infection of the Central Nervous System
R01


Sponsor: Multiple
Clinical Trials: Not Allowed
FOA: PA-20-151
Eradication of HIV-1 from Central Nervous system Reservoirs
R01


NIH FUNDING:
Other Deadlines

No New Listings


NIH
Notice of Special Interest (NOSI)

Thru: July 4
Sponsor: NIMH
Clinical Trials: Optional
NOSI: NOT-MH-20-05
HIV Pre-exposure Prophylaxis (PrEP) Implementation Science in HRSA Primary Health Care Settings
Admin Supplement



See previously advertised Funding Opportunities in Network News archived issues.

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Recent Pubs
that link to the CFAR grant
(P30 AI050409)

32409953
Onwubiko U, Holland D, Ajoku S, Taylor J, Childs A, Wilson D, Chamberlain AT. Using PrEP to #STOPHIVATL: Findings from a Cross-Sectional Survey Among Gay Men and Transgender Women Participating in Gay Pride Events in Atlanta, Georgia, 2018.
Arch Sex Behav. 2020 May 14. doi: 10.1007/s10508-020-01711-0. Online ahead of print.


32418165
Crockett KB, Esensoy TA, Johnson MO, Neilands TB, Kempf MC, Konkle-Parker D, Wingood G, Tien PC, Cohen M, Wilson TE, Logie CH, Sosanya O, Plankey M, Golub E, Adimora AA, Parish C, D Weiser S, Turan JM, Turan B. Internalized HIV Stigma and Pain among Women with HIV in the United States: The Mediating Role of Depressive Symptoms.
AIDS Behav. 2020 May 16. doi: 10.1007/s10461-020-02919-w. Online ahead of print.


32130178
Jones J, Dominguez K, Stephenson R, Stekler JD, Castel AD, Mena LA, Jenness SM, Siegler AJ, Sullivan PS. A Theoretically Based Mobile App to Increase Pre-Exposure Prophylaxis Uptake Among Men Who Have Sex With Men: Protocol for a Randomized Controlled Trial.
JMIR Res Protoc. 2020 Feb 21;9(2):e16231. doi: 10.2196/16231.


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    Calendar Upcoming Events

May 21
8:00 am
ID Seminar
FLU2: The Impact of Imprinting and Repeated Influenza Vaccination on Adaptive Immunity
Starring: Amy Sherman
Zoom Link

May 21
3:00
FB Live with Carlos del Rio
COVID-19: What You Need To Know
Attend the Event

Instructions:
1. Click the link above
2. Disregard the log in request
3. Click Videos on the left of the page
   This will link you to the "live" feed
4. Refresh the web page as needed
   until the livestream begins (5/7, 3pm)

May 22
1:00
Webcast
Vaginitis and Sexually Transmitted Infections in Women Who Have Sex with Women Webcast
Hosted by: Mississippi AETC
More Information
Registration

May 22
1:00
Webcast
Mental Health Effects and Coping with COVID-19 Pandemic
Hosted by: South Florida AETC
More Information
Registration

May 22
4:00 - 5:00
"Fridays at Four" Webinar
The Strategy and Logistics of Ramping Up Research
Hosted by: Emory Office of the Senior Vice President for Research
Registration

May 26
1:00
Webcast
Minding the Gap: Improving Perinatal HIV Service Coordination to Eliminate Mother-to-Chid Transmission
Hosted by: Georgia AETC
More Information
Registration

May 26 (Weekly on Tuesdays)
2:00
In-Tune
Practice Mindfulness by Reflecting on Music
Open to novice and expert practitioners of mindfulness
• Questions: Catherine Aniezue (catherine.ifunanya.aniezue@emory.edu)
Zoom Link

May 27
11:00
Webcast
A Game Changing Dialogue: PrEP Delivery and Differentiation
Hosted by: Georgia AETC
More Information
Registration

May 27
12:00
Webcast
Webcast Wednesday: Linkage to Care for Adolescents with Newly Acquired HIV
Hosted by: Tennessee AETC
More Information
Registration

May 28
1:00
Webcast
Addressing The Challenges Of HIV Primary Care In The Deep South
Hosted by: Mississippe AETC
More Information
Registration

May 29
9:00 - 12:00
Online Symposium
Neurosciences/NeuroAIDS
Hosted by: Miami CFAR
Information & Registration

Calendar Farther Down the Road

June 3 - New Listing
12:00
Webcast
Webcast Wednesday: Using Adult Learning Principles to Create Effective Training
Hosted by: Tennessee AETC
More Information
Registration

June 5 - New Listing
9:00 - 3:30pm
Webcast
Don't be a Backseat Driver! Lead the Way Toward an End to AIDS in the South
Hosted by: Georgia & North Florida AETCs
More Information
Registration

June 12 - New Listing
9:00 - Noon
Pediatric Research Webinar
COVID-19
Starring:
    Peter Hotez (Baylor)
    Evan Anderson
    Stefan Sarafianos
Register to Attendr
Add to Calendar
Flyer

August 4
Symposium
Annual Pediatric Research and Career Development
Keynote: Ann Chahroudi
More Information

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The Network News is a periodic email, detailing HIV/AIDS related events, funding opportunities, and achievements of CFAR members. If you have items that you wish to have included, please send them to us at cfar@emory.edu by Friday of each week. Please put "The Network News" in the subject line.

The Network News is distributed to CFAR members and fans by email every Wednesday. Except when it isn't.

Editor, Kimbi Sessions Hagen, EdD

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